DAUNORUBICIN HYDROCHLORIDE

Synonyms. Daunorubicin hydrochloride; (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro- 3,5,12-trihydroxy- 10-methoxy-6,11-dioxo-1-naphthacenyl 3-amino- 2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride; Cerubidine; Daunoblastin; Daunoblastina; Cérubidine; Daunoblastina; Ondena; Daunomycin hydrochloride; Leukaemomycin C; Rubidomycin; (8S-cis)-8-Acetyl-10-9(3-amino-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy- 1-methoxy-5,12- naphthacenedione;

 DAUNORUBICIN HYDROCHLORIDE

 

PRODUCT IDENTIFICATION

CAS RN

23541-50-6 (hydrochloride), 20830-81-3 (parent)

EINECS RN

245-723-4

FORMULA

 C27H29NO10·HCl

MOLE WEIGHT

563.98

H.S CODE

 2938.90.0000

SMILES

 C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@ ](Cc3c2 c(c4c (c3O )C (=O)c5cccc(c5C4=O)OC) O)(C(=O)C)O)N)O.Cl

CLASSIFICATION

Antineoplastic, Antibiotic, Anthracycline, Topoisomerase II Inhibitor

EXTRA NOTES

 A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.
Other RN: 52471-42-8

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellow to red crystalline powder

MELTING POINT

188 ~ 190 C (Decomposes)

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Soluble

SOLVENT SOLUBILITY Soluble in methanol. Slightly soluble in ethanol. Practically insoluble in chloroform, ether, benzene.

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pH

 

REFRACTIVE INDEX

 

FLASH POINT

 

 
STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2,Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Daunorubicin

Google Scholar Search - Daunorubicin hydrochloride

Drug Information Portal (U.S. National Library of Medicine) - Daunorubicin hydrochloride

PubChem Compound Summary - Daunorubicin hydrochloride

Drug Bank -  Daunorubicin

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Daunorubicin

http://www.ebi.ac.uk/ - Daunorubicin

http://www.ncbi.nlm.nih.gov/ - Daunorubicin hydrochloride

http://chemoth.com/
Anthracyclines are anticancer compounds that were originally derived from Streptomyces and their anti-tumor activities were established in the 1960s[1]. Anthracyclines are red aromatic polyketides and occur in variety of forms due to the structural differences in the aglycone and the different sugar residues attached[2].Major Drugs in the class. Daunorubicin - Daunomycin (daunorubicin) was the first anthracycline compound to be chatacterized structurally and stereochemically. Danorubicin is used in treating acute lymphoblastic and myeloblastic leukaemias.....

 

SALES SPECIFICATION

APPEARANCE

 yellow to red crystalline powder

IDENTIFICATION

positive (Test A,B)

POTENCY

940µg ~ 1050µg/mg (anhydrous basis)

ASSAY

98.5 ~ 100.5%
RELATED MATTERS

2.0% max
SPECIFIC ROTATION

+243° ~ +253° (c = 0.05 in MeOH)

HEAVY METALS

20ppm max
pH

4.5 ~ 6
RESIDUE ON IGNITION

0.1% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

Toxic if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of causing cancer. May be harmful if inhaled. May cause respiratory tract irritation. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation.

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301-H334-H351

P STATEMENTS

P261-P281-P301 + P310-P342 + P311

EC DIRECTIVES

 

HAZARD CODES

Xn

RISK PHRASES

22-40-42/43

SAFETY PHRASES

 22-36/37-45

 

PACKING